Analysis of Drug Utilization in Obstetric Patients of Our Hospital during Pregnancy / 中国药房

ABSTRACT

OBJECTIVE： To analyze the characteristics of pregnancy medication in obstetric patients of our hospital， and to provide reference for promoting rational drug use in obstetric department. METHODS： Using hospital information system， 30 prescriptions of women who produced in our hospital were randomly selected monthly from Jan. 2015 to 30th， 2017. The modes of production and pregnancy outcomes were recorded. The drugs used during pregnancy in our hospital were summarized. Statistical analysis was made on the number of cases， varieties and frequency of drug use in neonatal outcomes and different stages of pregnancy. The rationality of drug use in different stages of pregnancy was evaluated. RESULTS： Totally 1 076 valid prescriptions were collected， including 528， 343 and 205 cases aged 21-30， 31-34， 35 and above， 462 cases with cesarean and 614 patients with spontaneous labor， 1 041 cases with single fetus and 35 cases with twins， 1 089 neonates with APGAR score of 8-10，20 neonates with 4-7，and 2 neonates with 0-3， 96 neonates with low birth weight and 4 neonates with abnormal. The rate of drug use during pregnancy was as high as 96.65％ （1 040/1 076）. The utilization rate of drugs were 55.19％ （574/1 040）， 99.42％ （1 034/  1 040） and 57.98％ （603/1 040） in the first， second and third trimesters of pregnancy， involving 137 drugs. Classification of top 3 drugs in the list of frequency were drugs for digestive tract and metabolic diseases for Fuzheng agent （Chinese patent medicine） and for sex hormones and regulators of reproductive system in the first trimesters of pregnancy， and for digestive tract and metabolism， urinary and reproductive system and cardiovascular system in the second trimesters， for digestive tract and metabolism， blood and hematopoietic organs and systemic hormones except sex hormones and insulin in the third trimesters. There were unreasonable use of drugs in the first trimester and there were also abnormalities outcomes of birth， but the correlation between abnormalities and drugs used during pregnancy could not be determined in the study. CONCLUSIONS： The rate of drugs used during pregnancy was high， and the value of DDDs was highest in the second trimester； the types of drugs used in different periods basically accord with the epidemiological characteristics of pregnancy. However， there are some unreasonable medication problems and potential safety hazards in medication during pregnancy， which need to be further rectified. The correlation between adverse pregnancy outcomes and drugs used during pregnancy has not been determined， and needs to be studied with large sample data.