Pharmacoeconomic Evaluation of α-Lipoic Acid Alone or Combined with Mecobalamin versus Mecobalamin in the Adjunctive Treatment of Diabetic Peripheral Neuropathy / 中国药房
China Pharmacy
; (12): 689-693, 2019.
Article
in Zh
| WPRIM
| ID: wpr-817076
Responsible library:
WPRO
ABSTRACT
OBJECTIVE: To evaluate the clinical efficacy and economics of α-lipoic acid injection alone or combined with Mecobalamin injection versus Mecobalamin injection in the adjunctive treatment of diabetic peripheral neuropathy (DPN). METHODS: Retrieved from PubMed, Cochrane Library, Embase, CNKI, VIP, CBM and Wanfang database, using “mecobalamin” “α-lipoic acid” and“diabetic peripheral neuropathy”as Chinese retrieval words, “Thioctic acid” “α-lipoic acid” “Methylcobal” “Mecobalamin” “Diabetic peripheral neuropathy” as English retrieval words, relevant randomized controlled trials (RCTs) were collected during the date of database establishment to Aug. 30th, 2018. Meta-analysis was conducted for total response rate. From the perspective of health care providers, cost-effectiveness analysis was used for economic evaluation and sensitivity analysis was conducted by a 15% fluctuation of cost and total response rate. RESULTS: Totally 13 RCTs were included, involving 1 131 patients. The results of Meta-analysis showed that the total response rate of two-drug combination therapy in the treatment of DPN was higher than that of mecobalamin alone [RR=1.41, 95%CI(1.28, 1.55), P<0.000 01]; that of α-lipoic acid injection alone in the treatment of DPN was higher than that of mecobalamin injection alone [RR=1.35, 95%CI(1.25,1.47), P<0.000 01], with statistical significance. Results of cost-effectiveness analysis showed that the cost-effectiveness ratio (CER) of Mecobalamin injection was 211.38 yuan, and CER of two-drug combination and α-lipoic acid injection alone were 1 484.42 and 1 383.49 yuan, respectively. The incremental cost-effectiveness ratio (ICER) were 4 589.52 and 4 638.82 yuan, which were all lower than per capita GDP in 2017. Sensitivity analysis showed that the cost-effectiveness analysis results kept stable. CONCLUSIONS: Compared with Mecobalamin injection, α-lipoic acid injection combined with Mecobalamin injection in the adjunctive treatment of DPN show high total response rate and economics.
Full text:
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Index:
WPRIM
Type of study:
Clinical_trials
Language:
Zh
Journal:
China Pharmacy
Year:
2019
Type:
Article