Efficacy and Safety of Nalbuphine for Post-operative Analgesia :a Meta-analysis / 中国药房
China Pharmacy
;
(12): 528-532, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-817100
ABSTRACT
OBJECTIVE: To evaluate the efficacy and safety of nalbuphine for postoperative analgesia systematically, and to provide evidence-based reference in clinic. METHODS: Retrieved from Embase, Medline, PubMed, CNKI, VIP and Wanfang database, RCTs about nalbuphine hydrochloride (trial group) vs. other analgesics (control group) for postoperative analgesia were collected. After literature screening, data extraction and literature quality evaluation with modified Jadad scale, Meta-analysis was performed by using Rev Man 5.3 statistical software. RESULTS: A total of 10 RCTs were included, involving 796 patients. Results of Meta-analysis showed that there was no statistical significance in satisfaction rate of analgesia [OR=1.11,95%CI(0.70,1.74),P=0.66], the incidence of nausea [OR=1.20,95%CI(0.79,1.83),P=0.39], vomiting [OR=1.02,95%CI(0.69,1.50),P=0.92] or narcolepsy [OR=1.32,95%CI(0.47,3.76),P=0.06] between 2 groups. The incidence of pruritus [OR=0.29,95%CI(0.14,0.58),P=0.000 6], respiratory depression [OR=0.21,95%CI(0.08,0.58),P=0.003] and uroschesis [OR=0.05,95%CI(0.01,0.37),P=0.004] in trial group were significantly lower than control group. CONCLUSIONS: Nalbuphine has better efficacy and safety for postoperative analgesia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Systematic reviews
Language:
Chinese
Journal:
China Pharmacy
Year:
2019
Type:
Article
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