Clinical characteristics related to onset age of wheeze in school-age children and adolescents with asthma
Allergy, Asthma & Respiratory Disease
;
: 326-333, 2015.
Article
in Korean
| WPRIM
| ID: wpr-81730
ABSTRACT
PURPOSE:
We aimed to investigate the clinical characteristics and their relationship with the onset age of wheeze in school-age children and adolescents with asthma.METHODS:
Three hundred twenty-six patients, aged 6 to 19 years, diagnosed with asthma at 6 hospitals from Seoul, Gyeonggi, Daegu, and Busan were enrolled. They were categorized into 3 groups by the onset age of wheeze group A, early onset (age or =6 years). Clinical characteristics including atopic sensitization, family history, combined allergic diseases, severity of asthma, and influence of asthma on daily life were examined. A history of hospitalization for early lower respiratory infection (LRI) and environmental tobacco smoking were studied and lung function tests were also performed.RESULTS:
There was no difference in demographics, prevalence of atopy, combined allergic diseases, and family history of allergy between 3 groups. A history of sever LRI in early life was more common in groups A and B compared with group C. Sensitization to Dermatophagoides pteronyssinus was more prevalent in groups A and B than in group C. Forced expiratory flow between 25% to 75% (FEF(25%-75%)) was lower in groups A and B than in group C, and methacholine PC20 (provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one second) was lowest in group B. Significantly lower FEF(25%-75%) and methacholine PC20 were observed in the patients who had been hospitalized with LRI in early life.CONCLUSION:
Our study shows significant difference in lung function and atopic sensitization in relation to the onset age of wheeze in school-age children and adolescents with asthma, and suggests that early LRI might contribute to the development of asthma in early life.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Respiratory Function Tests
/
Asthma
/
Smoking
/
Demography
/
Forced Expiratory Volume
/
Prevalence
/
Methacholine Chloride
/
Age of Onset
/
Dermatophagoides pteronyssinus
/
Seoul
Type of study:
Prevalence study
Limits:
Adolescent
/
Child
/
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Allergy, Asthma & Respiratory Disease
Year:
2015
Type:
Article
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