Effects of Phenytoin on 3 Kinds of Cardiovascular Disease-related Factor in Patients with Epilepsy :A Meta-analysis / 中国药房
China Pharmacy
;
(12): 353-357, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-817344
ABSTRACT
OBJECTIVE:To systematically evaluate the effects of phenytoin on 3 kinds of cardiovascular disease-related factors (Folic acid ,vitamin B 12 and homocysteine)in epilepsy patients ,and to provide evidence-based reference for clinical treatment of epilepsy. METHODS :Retrieved from PubMed ,Google scholar ,CJFD,VIP and Wanfang database ,observational studies about using phenytoin (trial group ) versus using no antiepileptics (control group ) on the levels of folic acid ,vitamin B 12 and homocysteine in serum were collected during Jan. 1991-Jan. 2019. After data extraction of included literatures ,quality evaluation with evaluation criteria for cross-sectional study (AHRQ)scale,Rev Man 5.3 and Stata 11 softwares were used for statistical analysis. RESULTS :A total of 10 studies were included ,involving 745 patients. Meta-analysis showed that the folic acid level of trial group was significantly lower than control group [SMD =-0.90,95%CI(-1.18,-0.62),P<0.001];the level of homocysteine in trial group was significantly higher than control group [SMD =1.22,95%CI(0.73,1.71),P<0.001]. There was no significant difference in the levels of vitamin B 12 between 2 groups [SMD =- 0.19,95% CI(- 0.39,0.02),P>0.05]. CONCLUSIONS:Phenytoin can reduce the level of folic acid and increase the level of homocysteine in epilepsy patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Observational study
/
Systematic reviews
Language:
Chinese
Journal:
China Pharmacy
Year:
2020
Type:
Article
Similar
MEDLINE
...
LILACS
LIS