Effect of vitamin B6 deficiency on antioxidative status in rats with exercise-induced oxidative stress
Nutrition Research and Practice
;
: 208-211, 2009.
Article
in English
| WPRIM
| ID: wpr-81752
ABSTRACT
This study investigated the effect of vitamin B6 deficiency on antioxidant enzyme activities and lipid profile in rats with exercise-induced oxidative stress. Forty eight rats were fed either a vitamin B6 deficient diet (B6-) or a control diet (control) for 4 weeks and then subdivided into 3 groups pre-exercise (PreE); post-exercise (PostE); recess after exercise (recessE). Compared to those of control group, plasma catalase and hepatic cytosol superoxide dismutase (SOD, EC 1.15.1.1) activities of B6- group were lower regardless of exercise. The ratio of reduced glutathione/oxidized glutathione (GSH/GSSG) of B6- group was lower in PreE and there was no difference between PostE and recessE. The level of malondialdehyde (MDA) of B6- was significantly higher in PreE and PostE. High-density lipoprotein-cholesterol (HDL-C) level of B6- group was lower regardless of exercise. Atherosclerotic index of B6- group was higher in PreE and there was no difference between PostE and recessE. It is suggested that a reduction in antioxidative status caused by vitamin B6 deficiency may be aggravated under exercise-induced oxidative stress.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Vitamin B 6 Deficiency
/
Superoxide Dismutase
/
Vitamins
/
Catalase
/
Oxidative Stress
/
Vitamin B 6
/
Cytosol
/
Diet
/
Glutathione
Limits:
Animals
Language:
English
Journal:
Nutrition Research and Practice
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS