Change Rule of Telomere Length and The Aging Score Changing Trend in Different Aging Groups of Women / 中山大学学报(医学科学版)

ABSTRACT

@#【Objective】To explore the changing rules of telomere length and the scores trend in different aging groups of women. 【Methods】 The 20-year-old and above healthy women were randomly selected from several hospitals of Nanchang University. Peripheral blood samples were collected as test samples，relative length of telomere was detected and analyzed. Meanwhile，the aging score was measured by PPSHAS scale. 【Results】 A total of 406 effective samples were obtained in this study，and the difference of telomere relative length in different age groups was statistically significant（P<0.001）.The results showed that the relative length of telomere shortened with age，there is a highly negative correlation between telomere length（Y）and age（X；r=-0.623，P<0.001）. The regression equation is Y =-0.012X +1.984（P<0.001，R2=0.400）. Scores increased with age，and there was a distinct upward trend in 40~ and 60~ years old groups. The relative length of telomere decreased significantly，suggesting that there was a certain degree of agreement between them. Scores contributed to further research on female senescence. 【Conclusion】The telomere length of peripheral blood leukocytes in healthy women is shortened with age，and the relative length of telomere is negatively correlated with age. The change trend of telomere length and senescence score in 40~ and 60~ age groups suggests that women are rapidly aging at this stage and provide reference for the study of women′s elderly problem.