Meta-analysis of lung ultrasound for the diagnosis of neonatal pneumonia / 中国实用儿科杂志

ABSTRACT

OBJECTIVE: To evaluate the diagnostic value of lung ultrasound for neonatal pneumonia by Meta-analysis.METHODS: PubMed,Cochrane library,Embase,CNKI and Wanfang Database were searched from database establishment to September 2018 to gather articles according to the inclusion and exclusion criteria of diagnostic research. A total of 907 studies were retrieved. Eight studies were selected for analysis. QUADAS2 was used to evaluate the quality of articles included. Heterogeneity was assessed by using Q and I2 statistics. Meta-Disc 1.4 software was applied for the statistical analysis to evaluate the diagnostic value of lung ultrasound for neonatal pneumonia. RESULTS: A total of 8 articles involving 1078 cases were included. Random effect model was adopted for statistical analysis. The pooled sensitivity was0.96(95%CI0.95-0.98);the pooled specificity was 0.98(95%CI0.95-0.99);the pooled positive likelihood ratio was19.52(95%CI5.00-76.15);the pooled negative likelihood ratio was 0.04(95%CI0.01-0.16);the pooled odds ratio was 565.45(81.80-3908.58);the area under SROC was 0.9950. CONCLUSION: The sensitivity and specificity of lung ultrasound in the diagnosis of neonatal pneumonia are higher than X-ray. Considering the features of being easy,readily availability,low cost,and being free from radiological hazards,current evidence supports lung ultrasound as an imaging alternative for the diagnosis of neonatal pneumonia.