The progresses of molecular mechanism of Isoniazid resistance in Mycobacterium Tuberculosis / 医学研究生学报

ABSTRACT

Mycobacterium tuberculosis is the causative agent of tuberculosis, which is a threat to public health worldwide. Isoniazid is one of the most active compounds used to treat tuberculosis worldwide. The pro-drug isoniazid is activated by catalase-peroxidase (KatG), and the active isoniazid products are targeted to InhA. The molecular mechanisms of isoniazid resistance involve several genes mutations. Mutation in the katG gene is the major cause for isoniazid resistance, followed by inhA, kasA, oxyR . Efflux pump systems also play important role in conferring isoniazid resistance. Understanding the mechanisms operating behind isoniazid action and resistance would enable better diagnosis and treatment of isoniazid-resistant tuberculosis.