Progressesin endothelial progenitor cells derived extracellular vesicles / 医学研究生学报

ABSTRACT

Endothelial progenitor cells (EPCs) play an important role in angiogenesis and tissue repair, which have been used to treat various kinds of diseases associated with poor perfusion or organ dysfunction. In recent years, researches had shown that extracellular vesicles(EVs) are the important paracrine components of cells. They carry the protein, mRNA, miRNA and other bioactive substances from the original cells to the target cells, yielding a similar effect to stem cell transplantation. The effects of extracellular vesicles derived from endothelial progenitor cells (EPCs-EVs) have been explored in cardiovascular diseases, diabetes mellitus, and renal injury et al. This review covers the biological characteristics of EVs, the application and mechanism of EPCs-EVs in these studies.