Research progress on regulatory mechanism and therapeutic targets of hepatic cancer stem cells / 医学研究生学报

ABSTRACT

HCC is the 5th most common malignant cancer worldwide. The high rate of tumor recurrence and widespread metastasis are closely associated with low survival rates in cancer patients . Several studies have demonstrated hepatic cancer stem cells (HCSCs), also called tumor-initiating cells, are involved in regulation of HCC initiation, progression, metastasis, and drug resistance. Therefore ,in this review we integrated the latest research progress on HCSC, explained the main mechanism of signaling pathways such as TGF/β，Hippo-YAP/TAZ,Wnt/β protein,Hedgehog(Hh),etc. In the mwantime, we analyzed the potential therapeutic targets in signaling pathways to provid a new promising treatment strategies for chemotherapy drug resistance of liver tumor.