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Research of hyperoxia-inducedlung injury related signaling pathways / 医学研究生学报
Journal of Medical Postgraduates ; (12): 1333-1339, 2018.
Article in Chinese | WPRIM | ID: wpr-818039
Responsible library: WPRO
ABSTRACT
Mammals exposured to high volume fractional oxygen (hyperoxygen) are prone to go under oxidative stress, and activating inflammatory cells in the lung produce cytotoxic reactive oxygen species directly or indirectly, activate complex signaling pathways and epigenetic factors, causing lung epithelial cells and endothelial cell damage and death. In the hyperoxia-induced lung injury-related signaling pathways, the current research includes MAPK pathway, P13K/Akt pathway, TGF-β related pathway, NF-κB pathway, Wnt pathway, Rho/Rock pathway, Notch pathway, Shh pathway, AngⅡ-P22phox-ROS pathway, Src pathway and so on. This review summarizes the research of these signaling pathways in hyperoxia-induced lung injury.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Medical Postgraduates Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Medical Postgraduates Year: 2018 Type: Article