Research progress of pseudogene gene PTENP1 in human tumors / 医学研究生学报

ABSTRACT

Phosphatase and tension homolog pseudogene 1 (PTENP1) is a pseudogene of phosphatase and tension homology deletion (PTEN), a well-known carcinoma suppressor gene.It belongs to processed pseudogenes which is unable to encode functional proteins. Its transcription product is a member of long noncoding RNA(lncRNA) family. PTENP1 primarily modulates the expression of PTEN at the levels of epigenetics and post-transcription, and then it plays a significant role in inhibiting oncogenesis via the signaling pathways of PI3/AKT, MAPK etc. The present paper is intended to summarized the existing researches of PTENP1 in human tumors and provide some help for future studies.