Mechanism and influencing factors of Lgr5 in intestinal stem cells / 医学研究生学报

ABSTRACT

The leucine repeat-rich G-protein-coupled receptor 5 (Lgr5), which expressed at the bottom of the crypt, not only acts as a marker of intestinal stem cells, but also induces cytonemes for transfering signaling effectors by internalization, influences proliferation by Wnt /β-catenin pathway, and promotes cytoskeletal structure, cell adhesion of intestinal stem cells（ISCs） via the IQGAP1. In addition, Lgr5 can be affected by the regulation of IL-1β、IL-22、miR-100-5p and others. Besides, intestinal microbiota change the localization of Lgr5+ cells in cript to induce apoptosis increased. Therefore，Lgr5 is influenced by many factors, which may play an important role in the proliferation, differentiation and stability of ISCs.