Research progress of Hedgehog signaling pathway in renal fibrosis / 医学研究生学报

ABSTRACT

Renal fibrosis is a common pathological manifestation of most chronic kidney disease (CKD) and a major pathological change leading to end-stage renal disease. Recent studies have found that the Hedgehog (Hh) signaling pathway plays an important role in renal fibrosis. This pathway is different from the TGF-β and Wnt pathways that have been studied in the past. Its activation mainly directly targets the central event of renal fibrosis-activation, proliferation and transformation of myofibroblasts. It suggests that this pathway plays an important role in the process of renal fibrosis, and this pathway interacts with other pathways to promote the development of renal fibrosis. Further research into this pathway may provide new ideas for the treatment of renal fibrosis. This article reviews the relationship between Hh signaling pathway and renal fibrosis.