Influence of visceral fat area on the prognosis of laparoscopic radical resection in patients with colorectal cancer / 医学研究生学报

ABSTRACT

Objective The factors influencing the prognosis of laparoscopic radical resection of colorectal cancer remain controversial. This study was to investigate the effect of visceral fat area (VFA) on the prognosis of laparoscopic radical resection of colorectal cancer and provide evidence for evaluating the prognosis of patients with colorectal cancer. Methods A retrospective analysis was made on the clinical data of 218 patients undergoing laparoscopic radical resection of colorectal cancer in the Department of Gastrointestinal Surgery of Affiliated Hospital of Southwest Medical University from March 2013 to June 2014. The patients were divided into VFA-S group (VFA<100cm2, n=106) and VFA-L group (VFA≥100m2, n=112) according to the measured VFA values. The basic clinical data of the two groups were compared and the short-term and long-term prognosis of VFA were evaluated by logistic regression and Cox regression models. Results The incidence of complication and the incidence of minor complications (13.2%, 9.4%) in VFA group were significantly lower than those in control group (27.7%, 19.6%), and the difference was statistically significant (P<0.05). The overall survival rate of patients in VFA group at 1 year, 3 years, and 5 years (98.1%, 87.7%, 70.8%) was significantly greater than that of control group (93.8%, 67.9%, 58.0%), and the difference was statistically significant (P< 0.05). The disease-free survival rate (98.1%, 84.0%, 70.8%) at 1 year, 3 years, and 5 years after surgery was significantly higher in VFA group than that in control group (92.0%, 67.9%, 58.0%), and the difference was statistically significant (P <0.05). The Kaplan-Meier curve showed that the overall survival and disease-free survival (58.91 months, 57.82 months) in VFA group were significantly greater than those in control group (51.61 months, 50.60 months), and the difference was statistically significant (P<0.05). The overall survival and disease-free survival were associated with ASA classification, differentiation, TNM stage, and VFA (P<0.05). Conclusion VFA has an impact on short-term and long-term prognosis after laparoscopic radical resection of colorectal cancer. VFA≥100cm2 indicates that patients have a high possibility of postoperative complications and poor prognosis.