Research progress on Wnt3 gene polymorphism and susceptibility to non-syndromic cleft lip and palate / 医学研究生学报
Journal of Medical Postgraduates
;
(12): 1217-1221, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-818171
ABSTRACT
Non-syndromic cleft lip with/without cleft palate (NSCL/P) is a common congenital disease worldwide, and its etiology is related to the combination of genetic and environmental factors. Although genome-wide association analysis did not involve Single Nucleotide Polymorphisms (SNPs) in Wnt genes, it has been reported that SNPs in Wnt genes are related to NSCL/P, and the study of SNPs of Wnt genes and its corresponding phenotypic effect is helpful to explain the etiological mechanism of NSCL/P. In recent years, Wnt3 gene related to NSCL/P, rs142167, rs3809857, rs9890413 and other teratopoietic single nucleotide loci are the main teratopoietic single nucleotide loci studied most, and the research conclusions on the correlation between Wnt3 gene polymorphism and NSCL/P are obviously different in different populations. This paper reviews the research progress on the correlation between Wnt3 gene polymorphism and NSCL/P.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Medical Postgraduates
Year:
2019
Type:
Article
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