Research progress of the role of adipokines in diabetic cardiomyopathy / 医学研究生学报

ABSTRACT

Obesity is a major risk factor for the progression of cardiovascular disease. Adipose tissue is considered to be an endocrine organ that produces various secretory molecules, also known as adipocytokines, which are involved in the pathogenesis of obesity complications, including metabolic dysfunction and cardiovascular disease. From the perspective of mechanism, diabetic cardiomyopathy is a typical metabolic cardiovascular disease. This article reviews the role of several adipokines in the pathogenesis of diabetic cardiomyopathy (DCM) from the aspects of insulin resistance, oxidative stress, myocardial fibrosis, myocardial apoptosis and inflammatory response.