Research progress on active targeting effect of chitosan nano-delivery system improving microenvironment of solid tumors / 医学研究生学报

ABSTRACT

The tumor microenvironment is closely related to the development and progression of tumors. Chitosan has become a favorable nanocarrier for its biodegradability and biocompatibility. At present，there are two kinds of targeting ways existed in the nano-delivery system，including active and passive targeting. However，the active targeting has become the mainstream of researches owing to some factors that passive targeting contributes to drug maldistribution and high therapeutic concentration. This article reviews the important components of tumor microenvironment and the active targeting of chitosan delivery systemsand summarizes the application progress on chitosan and its derivatives actively targeting multiple components in solid tumor environment as well as perspectives on some unsolved problems.