Precise nano-targeted technology based on disease microenvironment targeting / 医学研究生学报

ABSTRACT

Research into the rational delivery and targeting of pharmaceutical, therapeutic, and diagnostic agents is at the forefront of projects in nanomedicine with the launch of ‘precision medicine’, and into the era of ‘precise’ targeted nano drug delivery system design. According to the lesion feature of disease endangering human health, it is one of the important strategies to design nano drug delivery system that targets each of the lesions which could change the distribution of drugs in the body, specifically increasing the concentration of drugs in the target sites and reducing the concentration of non-target sites, so as to enhance the efficacy, reduce adverse reactions and achieve precise nano-targeted treatment of diseases.at last. This article introduces the design principle and latest research progress of drug passive and active nano targeting delivery of drugs based on local microenvironment characteristics of lesions in tumors, atherosclerosis, inflammatory diseases in recent years, aiming to provide reference and basis for the design of more nano-targeted drug delivery systems for tumors and other diseases.