The application progress of tumor radiotherapy in combination with immune checkpoint blockade / 医学研究生学报

ABSTRACT

Nowadays, it has been widely reported that radiotherapy can synergize with immune checkpoint blockade to improve antitumor efficacy, which shows significant advantages in clinical practice. The value of radiotherapy combined with immune checkpoint blockade therapy mainly lies in three aspects improved local tumor control, stimulation of systemic immune response to induce abscopal effect and the elimination of acquired immunological tolerance to fractionated radiotherapy. Further research shows that radiotherapy combined with multiple checkpoint blockade, costimulatory molecules agonist, checkpoint gene knockout will contribute to the improved antitumor effect of the combined treatment model. Thus, this article reviewed the immunoregulation characteristics of tumor radiotherapy as well as the application status and research progress of tumor radiotherapy in combination with immune checkpoint blockade.