Maspin in tumor formation and progression / 医学研究生学报

ABSTRACT

Maspin gene is a tumor suppressor that encodes serine protease inhibitor. It was found that maspin could induce apoptosis, inhibit the invasion and metastasis of tumor cells, and suppress angiogenesis. In recent years, maspin has also been found to be associated with host immunity. The review is to summarize structure distribution, tumor inhibition mechanism and immunological correlation of maspin.