The role of intestinal microorganism in tumor treatment / 医学研究生学报

ABSTRACT

The intestinal microbiota plays a crucial role in the innate and acquired immune responses. It regulates cancer initiation, progression, and response to therapies. This article focuses on the effect of intestinal microbiota on chemotherapy and immunotherapy. Intestinal microorganisms can activate the peripheral immune system, induce anti-tumor immune surveillance. Specific bacteria significantly affects anti-tumor immunity and the response to chemotherapy and immunotherapy. Proliferation, metastasis of specific bacteria or using of antibiotics induced intestinal microbiota disorders can change the efficacy of chemotherapy and immunotherapy. In the future, precision medicine can predict the patients’ response to drugs through the composition of intestinal microbes, regulate the initiation and development of tumors and the response to treatment by changing the composition of intestinal microbiome.