The role of microRNA in chronic myeloid leukemia / 医学研究生学报
Journal of Medical Postgraduates
;
(12): 188-191, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-818400
ABSTRACT
Chronic myeloid leukemia(CML)is a common hematological malignancy. Although tyrosine kinase inhibitors(TKIs)have greatly improved the prognosis of CML patients,there are still several defects with TKI treatment including TKI resistance, toxic effects causing intolerance, etc. MicroRNA(miRNA) is a class of non-coding, single-stranded and small RNAs which encoded by endogenous genes and are about 19 to 24 nucleotides in length. miRNAs are closely related to the occurrence,development and prognosis of various tumors. In recent years,many studies have focused on the relationship betweenmiRNA and CML. In this paper,we review therelationship between miR-139-5p,miR-320a,miR-362-5p,miR-126, miR-199a/b-5p,miR-451 and CML .
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Medical Postgraduates
Year:
2020
Type:
Article
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