Establishment of Budd-Chiari syndrome models and related research advances / 临床肝胆病杂志

ABSTRACT

Budd-Chiari syndrome (BCS) is a clinical syndrome of portal hypertension caused by the occlusion of the hepatic vein or the inferior vena cava, with or without inferior vena cava hypertension, and the formation of inferior vena cava diaphragm and/or hepatic venous obstruction are the main features in the Chinese population. At present, little is known about the etiology and pathogenesis of BCS, and most of the studies are clinical studies of diagnosis and treatment strategies. There is a lack of experimental exploration and research on the pathogenesis of BCS, and stable models are a necessary condition for the research on pathogenesis. This article reviews and analyzes the methods for establishing BCS models, the features of each model, and related research advances, in order to provide a reliable experimental basis for the research on the etiology and pathogenesis of BCS.