Cytokine profile in murine toxoplasmosis
Asian Pacific Journal of Tropical Medicine
;
(12): 16-19, 2011.
Article
in English
| WPRIM
| ID: wpr-819569
ABSTRACT
OBJECTIVE@#To investigate which cytokines are produced after acute infection of mice with Toxoplasma gondii (T. Gondii) RH strain.@*METHODS@#Mus domesticus domesticus mice in infected group were inoculated with with highly virulent T. Gondii RH strain by intraperitoneally. Serum samples were obtained from infected and non-infected mice for cytokine levels for ELISA assay.@*RESULTS@#The concentrations of tumor necrosis factor-α, interferon-γ, interleukin (IL)-10 and IL-12 in the cardiac blood sample of the infected mice were significantly higher than those in uninfected controls (P0.05).@*CONCLUSIONS@#According to our findings, immune response into T helper type 1 was predominant during acute T. gondii infection. Further characterization and purification of Toxoplasma molecule(s) implicated in the regulation of cytokines could lead to the development of new drug prospects to control Toxoplasma infection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Toxoplasma
/
Blood
/
Enzyme-Linked Immunosorbent Assay
/
Chemistry
/
Toxoplasmosis
/
Cytokines
/
Th1 Cells
/
Serum
/
Allergy and Immunology
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2011
Type:
Article
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