Antimotility effects of extracts and fractions of Eastern Nigeria mistletoe (Loranthus micranthus Linn)
Asian Pacific Journal of Tropical Medicine
;
(12): 556-560, 2012.
Article
in English
| WPRIM
| ID: wpr-819633
ABSTRACT
OBJECTIVE@#To evaluate the antimotility activity of Eastern Nigerian mistletoe[Loranthus micranthus (L. micranthus) Linn] parasitic on six different host trees viz. Baphia nitida, Persia americana, Kola accuminata, Irvingia gabonensis, Citrus simensis and Pentacletra macrophylla (P. mycrophylla).@*METHODS@#The antimotility of the methanol extracts and solvent fractions were evaluated in castor oil induced diarrheoa in rats.@*RESULTS@#The methanol extracts (200 mg/kg, i.p.) inhibited defeacation significantly (P < 0.05) 4 h after administration (75.73% to 93.33%) more than that of atropine sulphate (2 mg/kg, i.p.) which inhibited defeacation by 80.0%. The methanol extract (200 mg/kg, i.p.) of L. micranthus parasitic on P. mycrophylla exhibited significant (P<0.05) inhibition in gastrointestinal transit (67.6%) more than that of atropine sulphate (2 mg/kg, i.p.) which inhibited gastrointestinal transit by 26.4%. The solvent fractions of L. micranthus parasitic on P. mycrophylla at dose levels of 150 mg/kg inhibited significantly the gastrointestinal transit of mice. Fraction F(5) exhibited inhibitory activity which was comparable to loperamide (73.3%).@*CONCLUSION@#The methanol extract of L. micranthus parasitic on P. macrophylla exhibits higher antimotility activity that other extracts. The solvent fractions could serve as source of novel antimotility agents.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Castor Oil
/
Plant Extracts
/
Random Allocation
/
Cathartics
/
Analysis of Variance
/
Rats, Wistar
/
Plant Leaves
/
Loranthaceae
/
Defecation
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2012
Type:
Article
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