Whole Leea macrophylla ethanolic extract normalizes kidney deposits and recovers renal impairments in an ethylene glycol-induced urolithiasis model of rats
Asian Pacific Journal of Tropical Medicine
;
(12): 533-538, 2012.
Article
in English
| WPRIM
| ID: wpr-819637
ABSTRACT
OBJECTIVE@#To investigate the antilithiatic effect of the whole Leea macrophylla (L. macrophylla) Roxb (Leeaceae) ethanol extract in ethylene glycol-induced urolithiasis model of rats.@*METHODS@#Forty two seven weeks old male wistar albino rats were randomly divided into two major groups namely preventive (n=18) and therapeutic (n=24). Preventive group was further subdivided into 3 groups of 6 rats namely preventive control (PC), preventive lithiatic control (PLC) and preventive lithiatic L. macrophylla (PLLM). Similarly, therapeutic group was also subdivided into 4 groups of 6 rats namely therapeutic control (TC), therapeutic lithiatic control (TLC), therapeutic lithitatic L. macrophylla (TLLM) and therapeutic lithiatic cystone (TLCYS). The lithiasis was induced by 0.75% (v/v) ethylene glycol in the drinking water of all groups except the PC and TC groups. The urinary ionic parameters such as calcium, inorganic phosphate, oxalate, magnesium & creatinine and renal morphology were altered by ethylene glycol, which were partially recovered by 14 d preventive and almost fully recovered by 28 d therapeutic intervention trials with L. macrophylla extract (500 mg/kg BW daily).@*RESULTS@#Significant difference on recovery was observed between preventive and therapeutic interventional trials. Anti-urolithiatic effect of cystone was significantly (P<0.001) higher than extracts. L. macrophylla extract was found nontoxic in the acute toxicity test.@*CONCLUSION@#The results of this study demonstrated very promising anti-urolithiatic effect of L. macrophylla extract with preventive and therapeutic treatments in this experimental condition.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organ Size
/
Pathology
/
Pharmacology
/
Urine
/
Wound Healing
/
Calcium Oxalate
/
Calcium Phosphates
/
Plant Extracts
/
Kidney Calculi
/
Random Allocation
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2012
Type:
Article
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