Decreased proliferation ability and differentiation potential of mesenchymal stem cells of osteoporosis rat
Asian Pacific Journal of Tropical Medicine
;
(12): 358-363, 2014.
Article
in English
| WPRIM
| ID: wpr-819671
ABSTRACT
OBJECTIVE@#To explore decreased proliferation ability and differentiation potential of mesenchymal stem cells (MSCs) of osteoporosis rat.@*METHODS@#MSCs were obtained from osteoporosis rat, and proliferation potency and impaired osteogenic differentiation potential were determined.@*RESULTS@#The result showed a significant downregulation of MSCs pluripotency related gene (Oct 4) and osteogenic genes (BSP, OCN) expression in OVX MSCs compared with Sham MSCs (P<0.05).@*CONCLUSIONS@#These data suggest that MSCs are aging in osteoporosis body, and autologous OVX MSCs transplantation is not appropriate to treat osteoporosis if necessary. There will be a possibility in establishing a new clinical application of MSCs autologous transplantation to treat osteoporosis, if OVX MSCs have stronger proliferation and differentiation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoporosis
/
Physiology
/
Ovariectomy
/
Cell Differentiation
/
Rats, Sprague-Dawley
/
Cell Biology
/
Cell Proliferation
/
Disease Models, Animal
/
Mesenchymal Stem Cells
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2014
Type:
Article
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