Effect of RSCs combined with COP-1 on optic nerve damage in glaucoma rat model
Asian Pacific Journal of Tropical Medicine
;
(12): 317-320, 2014.
Article
in English
| WPRIM
| ID: wpr-819680
ABSTRACT
OBJECTIVE@#To explore effect of retinal stem cells (RSCs) combined with copolymer-1 (COP-1) immunotherapy on optic nerve damage in glaucoma rat model.@*METHODS@#A total of 40 SD rats were selected for glaucoma model and were randomly divided into 4 groups to observe protective effects of RSCs transplantation combined with COP-1.@*RESULTS@#Brain-derived neurotrophic factor (BDNF) and insulin like growth factor-1 (IGF-1) were either positive in retina of RSCs transplanted or COP-1 immunological treated rat. Positive rate of BDNF and IGF-1 and expression of mRNA and protein were significantly higher in RSCs transplantation combined with COP-1 immunotherapy treated rats compared with the other 3 groups, in which amount of apoptotic RGCs was lowest.@*CONCLUSIONS@#RSCs transplantation combined with COP-1 immunotherapy can promote the secretion of BDNF and IGF-1. They protect RGCs in glaucoma rats in coordination, significantly reduce the number of apoptosis RGCs so as to alleviate the optic nerve damage. It ponits a new research direction for treatment of glaucoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptides
/
Pharmacology
/
Retina
/
Stem Cells
/
General Surgery
/
Therapeutics
/
RNA, Messenger
/
Insulin-Like Growth Factor I
/
Chi-Square Distribution
/
Cells, Cultured
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS