Effect and mechanism of salvianolic acid B on the myocardial ischemia-reperfusion injury in rats
Asian Pacific Journal of Tropical Medicine
;
(12): 280-284, 2014.
Article
in English
| WPRIM
| ID: wpr-819688
ABSTRACT
OBJECTIVE@#To investigate the effect of salvianolic acid B on rats with myocardial ischemia-reperfusion injury.@*METHODS@#SD rats were randomly divided into five groups (n=10 in each group) A sham operation group, B ischemic reperfusion group model group, C low dose salvianolic acid B group, D median dose salvianolic acid B group, E high dose salvianolic acid B group. One hour after establishment of the myocardial ischemia-reperfusion model, the concentration and the apoptotic index of the plasma level of myocardial enzymes (CTn I, CK-MB), SOD, MDA, NO, ET were measured. Heart tissues were obtained and micro-structural changes were observed.@*RESULTS@#Compared the model group, the plasma CTn, CK-MB, MDA and ET contents were significantly increased, NO, T-SOD contents were decreased in the treatment group (group C, D, and E) (P<0.05); compared with group E, the plasma CTn I, CK-MB, MDA and ET levels were increased, the NO, T-SOD levels were decreased in groups C and D (P<0.05). Infarct size was significantly reduced, and the myocardial ultrastructural changes were improved significantly in treatment group.@*CONCLUSIONS@#Salvianolic acid B has a significant protective effect on myocardial ischemia-reperfusion injury. It can alleviate oxidative stress, reduce calcium overload, improve endothelial function and so on.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxidoreductases
/
Pathology
/
Pharmacology
/
Benzofurans
/
Blood
/
Myocardial Reperfusion Injury
/
Rats, Sprague-Dawley
/
Apoptosis
/
Troponin I
/
Protective Agents
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2014
Type:
Article
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