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Correlations of β-catenin, Ki67 and Her-2/neu with gastric cancer
Asian Pacific Journal of Tropical Medicine ; (12): 257-261, 2014.
Article in English | WPRIM | ID: wpr-819693
ABSTRACT
OBJECTIVE@#To study the clinical pathologic characteristics of β-catenin, Ki67 and Her-2/neu in gastric cancer and the correlation of β-catenin and Ki67 to the protein expression and gene conditions of Her-2/Neu.@*METHODS@#The protein expression of β-catenin, Ki67 and Her-2/Neu was detected by immunohistochemistry in 101 cases of gastric cancer and the gene conditions of Her-2/Neu by fluorescence in situ hybridization (FISH).@*RESULTS@#The protein expression of β-catenin, Ki67 and Her-2/Neu had close relationship with the clinical pathologic characteristics of gastric cancer. The β-catenin and Ki67 had obvious correlation to the differentiation, infiltration and lymphatic metastasis of the gastric cancer (P<0.05). The Ki67 had close relationship with the tumor-node-metastasis staging staging of gastric cancer (P<0.05). Her-2/Neu had close relationship with the differentiation and tumor-node-metastasis staging of gastric cancer (P<0.05) but had no relationship with the infiltration and lymphatic metastasis of the gastric cancer (P<0.05). The protein expression of Ki67 had significantly positive correlation to the protein expression and gene amplification conditions of Her-2/Neu (r=0.567, P<0.05 for protein; r=0.304, P<0.05 for gene).@*CONCLUSIONS@#Combined detection of β-catenin, Ki67 and Her-2/Neu can be used as a reliable method to help the observation of biological behavior, diagnosis and prognosis of gastric cancer, and Ki67 can be used to serve the preliminary screening of Her-2/Neu gene state.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Stomach Neoplasms / Blood / Immunohistochemistry / Biomarkers, Tumor / In Situ Hybridization, Fluorescence / Statistics, Nonparametric / Receptor, ErbB-2 / Ki-67 Antigen / Beta Catenin Type of study: Prognostic study Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Asian Pacific Journal of Tropical Medicine Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Stomach Neoplasms / Blood / Immunohistochemistry / Biomarkers, Tumor / In Situ Hybridization, Fluorescence / Statistics, Nonparametric / Receptor, ErbB-2 / Ki-67 Antigen / Beta Catenin Type of study: Prognostic study Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Asian Pacific Journal of Tropical Medicine Year: 2014 Type: Article