Hepatic effect of NAC on sevear acute pancteatise of rats
Asian Pacific Journal of Tropical Medicine
;
(12): 141-143, 2014.
Article
in English
| WPRIM
| ID: wpr-819716
ABSTRACT
OBJECTIVE@#To analyze the hepatic protection of n-acetyl cysteine (NAC) on severe acute pancreatitis (SAP).@*METHODS@#SD rats were randomly divided into control group, SAP group and NAC group. SAP AHO method was adopted to establish the model, 2 h after modeling, rats in NAC group had intraperitoneal injection of NAC (200 mg/kg). Ten rats from each group were sacrificed in every 6 and 12 h at different time points respectively. Liver damage, liver function and serum amylase, AST, ALT and malondialdehyde (MDA) were determined.@*RESULTS@#Serum amylase, AST, ALT and MDA content in SAP, NAC group at each time point were significantly higher in the control group (P<0.05), serum amylase, AST, ALT and MDA content in NAC group rats were lower in the SAP group significantly (P<0.05); Microscopic examination showed that the liver injury in rats and the NAC group significantly reduced in the SAP group.@*CONCLUSIONS@#NAC provides effective protection against liver damage to SAP, protective from SAP liver injury.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancreatitis
/
Pathology
/
Pharmacology
/
Acetylcysteine
/
Blood
/
Random Allocation
/
Rats, Sprague-Dawley
/
Drug Therapy
/
Enzymes
/
Liver
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2014
Type:
Article
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