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Co-positivity of anti-dengue virus and anti-Japanese encephalitis virus IgM in endemic area: co-infection or cross reactivity?
Asian Pacific Journal of Tropical Medicine ; (12): 124-129, 2014.
Article in English | WPRIM | ID: wpr-819719
ABSTRACT
OBJECTIVE@#To report high co-positivity of anti-dengue virus (DV) and anti-Japanese encephalitis virus (JEV) IgM in an area endemic for both the viruses and to discuss the possibilities of co-infection.@*METHODS@#Serum samples from the patients who presented with fever, suspected central nervous system infection and thrombocytopenia, were tested for anti-DV IgM and anti-JEV IgM antibodies. Conventional reverse transcriptase polymerase chain reaction was done for detection of DV RNA and JEV RNA.@*RESULTS@#Of 1 410 patient sera tested for anti-DV and anti-JEV antibodies, 129 (9.14%) were co-positive for both. This co-positivity was observed only in those months when anti-JEV IgM positivity was high. Titers of both anti-DV IgM and anti-JEV IgM were high in most of the co-positive cases. Among these 129 co-positive cases, 76 were tested by conventional reverse transcriptase polymerase chain reaction for both flaviviruses, of which eight cases were co-positive for DV and JEV.@*CONCLUSIONS@#Co-infection with more than one flavivirus species can occur in hyperendemic areas.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Immunoglobulin M / Epidemiology / Cohort Studies / Encephalitis, Japanese / Endemic Diseases / Cross Reactions / Dengue / Dengue Virus / Encephalitis Virus, Japanese Type of study: Etiology study / Incidence study / Observational study / Risk factors Limits: Adolescent / Child / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Asian Pacific Journal of Tropical Medicine Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Immunoglobulin M / Epidemiology / Cohort Studies / Encephalitis, Japanese / Endemic Diseases / Cross Reactions / Dengue / Dengue Virus / Encephalitis Virus, Japanese Type of study: Etiology study / Incidence study / Observational study / Risk factors Limits: Adolescent / Child / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Asian Pacific Journal of Tropical Medicine Year: 2014 Type: Article