Relationship between expression of COX-2, TNF-α, IL-6 and autoimmune-type recurrent miscarriage
Asian Pacific Journal of Tropical Medicine
;
(12): 990-994, 2013.
Article
in English
| WPRIM
| ID: wpr-819743
ABSTRACT
OBJECTIVE@#To investigate the roles of COX-2, TNF-α, IL-6 in the pathogenesis of autoimmune-type recurrent spontaneous abortion (RSA).@*METHODS@#RT-PCR was used to detect the mRNA of COX-2, TNF-α, IL-6 in the trophoblast cells of murine RSA and normal pregnant models. The COX-2, TNF-α, IL-6 protein expressions were determined by using immunohistochemisry staining method. The COX-2, TNF-α, IL-6 protein expressions were determined by ELISA.@*RESULTS@#The embryo loss rates in experiment group was significantly higher than that in normal pregnancy control group, the expression of COX-2, TNF-α, IL-6 in the trophoblast cells of murine RSA and normal pregnant models. The expression of COX-2 in autoimmune-type recurrent spontaneous abortion was significantly lesser than in normal pregnant models. The expression of TNF-α, IL-6 in autoimmune-type recurrent spontaneous abortion was significantly higher than in normal pregnant models. There was a positively correlation between TNF-α and IL-6. There was no relationship between COX-2, TNF-α and IL-6.@*CONCLUSIONS@#The abnormal expression of COX-2, TNF-α and IL-6 may result in RSA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Trophoblasts
/
Blood
/
Autoimmunity
/
Chemistry
/
Abortion, Habitual
/
Interleukin-6
/
Tumor Necrosis Factor-alpha
/
Statistics, Nonparametric
/
Maternal-Fetal Relations
/
Disease Models, Animal
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2013
Type:
Article
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