Ameliorative effects of standardized extract from Trigonella foenum-graecum L. seeds on painful peripheral neuropathy in rats

ABSTRACT

OBJECTIVE@#To evaluate the effects of the standardized extract of fenugreek (Trigonella foenum-graecum L. Family Leguminasae) seed (IND01) in animal models of peripheral neuropathy.@*METHODS@#IND01 was prepared from fenugreek seeds and standardized by high performance liquid chromatography to a marker compound, trigonelline. The effects of daily oral administration of IND01 (50, 100 and 200 mg/kg) were studied in rats after partial sciatic nerve ligation (PSNL) and sciatic nerve crush injury (SNCI) during 30-days period. The measurements on thermal hyperalgesia (TH), motor function test (MFT) score and motor nerve conduction velocity (MNCV) were recorded.@*RESULTS@#IND01 offered sustained protection against TH and deranged MFT scores in both models from 7-day onwards. Fifteen days of daily oral administration of IND01 restored MNCV reduction in rats with SNCI but not with PSNL.@*CONCLUSIONS@#IND01 was found to be effective in rat models of painful peripheral neuropathy.