Influence of Withania somnifera on obsessive compulsive disorder in mice
Asian Pacific Journal of Tropical Medicine
;
(12): 380-384, 2012.
Article
in English
| WPRIM
| ID: wpr-819763
ABSTRACT
OBJECTIVE@#To study the influence of methanolic and aqueous extract of Withania somnifera (W. somnifera) root on the marble-burying behavior of mice a well-accepted model of obsessive compulsive behavior.@*METHODS@#Mice were divided in different groups (n = 6). Fluoxetine (5, 10, 15 mg/kg), (10, 25, 50, 100 mg/kg) and methanolic extract W. somnifera (MEWS) (10, 25, 50, 100 mg/kg) were administered i.p. 30 min. prior to the assessment of marble burying behavior and locomotor activity. The control group received vehicle of the extract.@*RESULTS@#Administration of aqueous extracts W. somnifera (AEWS) and MEWS (50 mg/kg) successively decreased the marble burying behavior activity without affecting motor activity. This effect of AEWS and MEWS was comparable to standard fluoxetine, ritanserin and parachlorophenylalanine.@*CONCLUSIONS@#W. somnifera extract is effective in treating obsessive compulsive disorder.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Anti-Anxiety Agents
/
Plant Extracts
/
Analysis of Variance
/
Ritanserin
/
Plant Roots
/
Withania
/
Drug Therapy
/
Phytotherapy
/
Methods
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2012
Type:
Article
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