In-vitro cytotoxic activity of β-Sitosterol triacontenate isolated from Capparis decidua (Forsk.) Edgew
Asian Pacific Journal of Tropical Medicine
;
(12): 225-230, 2012.
Article
in English
| WPRIM
| ID: wpr-819794
ABSTRACT
OBJECTIVE@#To study the isolation and characterization of the constituent responsible for the cytotoxic activity of the ethanolic extract of stem of Capparis decidua (C. decidua).@*METHODS@#The preliminary cytotoxic effect of isolated compound (β-Sitosterol triacontenate) was investigated by MTT assay on A549 solid tumor cells.@*RESULTS@#IC(50) value of the β-Sitosterol triacontenate was found to be 1 μM. The cytotoxic activity increased in a dose dependent manner in case of β-Sitosterol triacontenate.@*CONCLUSIONS@#The data therefore provide direct evidence for the role of β-Sitosterol triacontenate as a potent antimetastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Sitosterols
/
Enzyme-Linked Immunosorbent Assay
/
Plant Extracts
/
Magnetic Resonance Spectroscopy
/
Chemistry
/
Plant Stems
/
Capparis
/
Cell Line, Tumor
/
Drug Therapy
Limits:
Humans
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2012
Type:
Article
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