Gastroprotective effect of Achyranthes aspera Linn. leaf on rats
Asian Pacific Journal of Tropical Medicine
;
(12): 197-201, 2012.
Article
in English
| WPRIM
| ID: wpr-819799
ABSTRACT
OBJECTIVE@#The study was aimed at evaluating the antiulcer activity of ethanolic extract of Achyranthes aspera (EEAA) leaf.@*METHODS@#The anti-ulcer assays were performed on pylorus ligation and chronic ethanol induced ulcer model. The effects of the EEAA on gastric content volume, pH, free acidity, total acidity and ulcer index were evaluated.@*RESULTS@#The percentage of ulcer protection (59.55% and 35.58%) was significantly (P < 0.001) higher in the groups treated with the high dose of EEAA (600 mg/kg), it also reduced the volume of gastric juice and total acidity whereas, gastric pH was increased significantly.@*CONCLUSIONS@#The results of this study show significant gastroprotective activity of EEAA may be due to presence of phyto-constituents like flavanoids, saponins and tannins.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Solvents
/
Stomach Ulcer
/
Plant Extracts
/
Chemistry
/
Chronic Disease
/
Plant Leaves
/
Achyranthes
/
Ethanol
/
Drug Therapy
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2012
Type:
Article
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