Study of the hippocampus and the anterior cingulate gyrus by proton MR spectroscopy in patients with post-traumatic stress disorder
Asian Pacific Journal of Tropical Medicine
; (12): 162-164, 2012.
Article
in En
| WPRIM
| ID: wpr-819806
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To explore the characteristics of metabolic changes in patients with post-traumatic stress disorder through 1H-MRS in neuroanatomical circuit comparing with age-matches controls.@*METHODS@#Fifty patients with post-traumatic stress disorder and 50 gender-and age-matched normal controls were involved. The neurochemical abnormalities including the levels of choline (Cho)/creatine(Cr) and N-acetylaspartate (NAA)/Cr were measured respectively in hippocampus and the anterior cingulate gyrus with three-dimension 1H-proton spectroscopy(3D 1H-MRS).@*RESULTS@#The values of NAA/Cr ratios in hippocampus and the anterior cingulate gyrus were significant lower in patients with post-traumatic stress disorder(1.71±0.32, left 1.58±0.29, right 1.55±0.31) than that in controls(2.24±0.41, left 1.98±0.27, right 2.02±0.36)(P<0.05), but the values of Cho/Cr in hippocampus(left 1.64±0.23, right 1.66±0.34) were no significant with that of controls (left 1.48±0.29, right 1.54±0.38). Values of Cho/Cr in cingulate gyrus were significant higher in post-traumatic stress disorder patients (1.88±0.44) than that in controls (1.37.±0.32) (P<0.05).@*CONCLUSIONS@#The results indicate some special neurochemical and histological structure changes in post-traumatic stress disorder patients, which might occurre earlier in anterior cingulate gyrusthe than in hippocampus.
Full text:
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Index:
WPRIM
Main subject:
Pathology
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Protons
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Stress Disorders, Post-Traumatic
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Magnetic Resonance Spectroscopy
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China
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Choline
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Epidemiology
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Aspartic Acid
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Creatine
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Diagnosis
Type of study:
Diagnostic_studies
Limits:
Adolescent
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Adult
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Female
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Humans
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Male
Country/Region as subject:
Asia
Language:
En
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2012
Type:
Article