Antidiarrheal activity of Pterocarpus erinaceus methanol leaf extract in experimentally-induced diarrhea
Asian Pacific Journal of Tropical Medicine
;
(12): 147-150, 2012.
Article
in English
| WPRIM
| ID: wpr-819809
ABSTRACT
OBJECTIVE@#To investigate the antidiarrheal activity of the methanol leaf extract of Pterocarpus erinaceus in vivo.@*METHODS@#The methanol leaf extract of Pterocarpus erinaceus was evaluated using different doses (100, 200 and 400 mg/kg body weight) orally for antidiarrheal activity using castor oil-induced diarrhea, charcoal meal transit time and castor oil-induced enteropooling in different groups of albino Wistar mice. The activity of the extract at different doses were compared to diphenoxylate (5 mg/kg) and atropine sulphate (3 mg/kg) which were used as standard reference drugs and also to the distilled water administered negative control group of mice.@*RESULTS@#The extract at the doses used caused a significant (P< 0.01) reduction in the wet faeces passed by the mice in the castor oil-induced diarrhea, decreased the distance travelled by the charcoal meal by up to 54.8% and also caused a dose dependent and significant (P< 0.001) reduction in the intraluminal fluid accumulation in the castor oil-induced enteropooling.@*CONCLUSIONS@#Our results indicate that Pterocarpus erinaceus extract produced significant antidiarrheal activity and the action may attribute to inhibition of gastrointestinal movement and fluid secretion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Castor Oil
/
Plant Extracts
/
Chemistry
/
Rats, Wistar
/
Plant Leaves
/
Pterocarpus
/
Diarrhea
/
Methanol
/
Drug Therapy
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS