Antimalarial potency of the leaf extract of Aspilia africana (Pers.) C.D. Adams
Asian Pacific Journal of Tropical Medicine
;
(12): 126-129, 2012.
Article
in English
| WPRIM
| ID: wpr-819813
ABSTRACT
OBJECTIVE@#To investigate the antimalarial activity of ethanol extract of Aspilia africana (A. africana) leaf.@*METHODS@#The ethanol extract of A. africana leaf (100-400 mg/kg) was screened for blood schizonticidal effect against chloroquine-sensitive Plasmodium berghei (P. berghei) in mice both in early and established models of antimalarial studies.@*RESULTS@#The leaf extract exhibited significant (P<0.05) antiplasmodial activity in 4-day early infection and in established infection tests with a considerable mean survival time comparable to that of standard drug, chloroquine (10 mg/kg).@*CONCLUSIONS@#The findings show that ethanol extract of A. africana leaf possesses potent antiplasmodial activity which justify the use in ethnomedicine and can be developed in malaria therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Plasmodium berghei
/
Solvents
/
Plant Extracts
/
Chemistry
/
Analysis of Variance
/
Plant Leaves
/
Asteraceae
/
Ethanol
/
Drug Therapy
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2012
Type:
Article
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