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Effect of intestinal function-recovering decoction on treatment of multiple organ dysfunction syndrome in rats
Asian Pacific Journal of Tropical Medicine ; (12): 889-892, 2013.
Article in English | WPRIM | ID: wpr-819953
ABSTRACT
OBJECTIVE@#To analyze the effect of intestinal function-recovering decoction on multiple organ dysfunction syndrome in rats, and to investigate a novel solution to multiple organ dysfunction syndrome.@*METHODS@#Multiple organ dysfunction syndrome was induced in 60 Sprague-Dawley rats by intestinal ischemia-reperfusion combined with cecal ligation and puncture. Then these rats were intragastrically administered physiological saline (group I, n=20), ampicillin (group II, n=20) or intestinal function-recovering decoction (group III, n=20). After treatment, serum malondialdehyde and superoxide dismutase levels were compared among three groups. Simultaneously, bacterial culture of various organ tissues was performed and bacterial and endotoxin translocation were observed.@*RESULTS@#Compared with group I, serum malondialdehyde, alanine aminotransferase and aspartate aminotransferase levels were significantly decreased (all P0.05). The rate of bacterial translocation in the groups II and III was significantly lower than in the group I (P0.05).@*CONCLUSIONS@#Intestinal function-recovering decoction can significantly reduce endotoxin and bacterial translocation and stabilize enteral oxidative-antioxidative balance.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Superoxide Dismutase / Blood / Drugs, Chinese Herbal / Rats, Sprague-Dawley / Bacterial Translocation / Disease Models, Animal / Drug Therapy / Endotoxins / Ampicillin Limits: Animals Language: English Journal: Asian Pacific Journal of Tropical Medicine Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Superoxide Dismutase / Blood / Drugs, Chinese Herbal / Rats, Sprague-Dawley / Bacterial Translocation / Disease Models, Animal / Drug Therapy / Endotoxins / Ampicillin Limits: Animals Language: English Journal: Asian Pacific Journal of Tropical Medicine Year: 2013 Type: Article