Molecular Imaging for Theranostics in Gastroenterology: One Stone to Kill Two Birds
Clinical Endoscopy
;
: 383-388, 2014.
Article
in English
| WPRIM
| ID: wpr-81996
ABSTRACT
Molecular imaging in gastroenterology has become more feasible with recent advances in imaging technology, molecular genetics, and next-generation biochemistry, in addition to advances in endoscopic imaging techniques including magnified high-resolution endoscopy, narrow band imaging or autofluorescence imaging, flexible spectral imaging color enhancement, and confocal laser endomicroscopy. These developments have the potential to serve as "red flag" techniques enabling the earlier and accurate detection of mucosal abnormalities (such as precancerous lesions) beyond biomarkers, virtual histology of detected lesions, and molecular targeted therapy-the strategy of "one stone to kill two or three birds"; however, more effort should be done to be "blue ocean" benefit. This review deals with the introduction of Raman spectroscopy endoscopy, imaging mass spectroscopy, and nanomolecule development for theranostics. Imaging of molecular pathological changes in cells/tissues/organs might open the "royal road" to either convincing diagnosis of diseases that otherwise would only be detected in the advanced stages or novel therapeutic methods targeted to personalized medicine.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Mass Spectrometry
/
Spectrum Analysis, Raman
/
Biochemistry
/
Birds
/
Biomarkers
/
Diagnosis
/
Endoscopy
/
Molecular Imaging
/
Precision Medicine
/
Optical Imaging
Type of study:
Diagnostic study
/
Prognostic study
Language:
English
Journal:
Clinical Endoscopy
Year:
2014
Type:
Article
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