Bioinformatics analysis of breast cancer bone metastasis related gene-CXCR4
Asian Pacific Journal of Tropical Medicine
;
(12): 732-738, 2013.
Article
in English
| WPRIM
| ID: wpr-819975
ABSTRACT
OBJECTIVE@#To analyze breast cancer bone metastasis related gene-CXCR4.@*METHODS@#This research screened breast cancer bone metastasis related genes by high-flux gene chip.@*RESULTS@#It was found that the expressions of 396 genes were different including 165 up-regulations and 231 down-regulations. The expression of chemokine receptor CXCR4 was obviously up-regulated in the tissue with breast cancer bone metastasis. Compared with the tissue without bone metastasis, there was significant difference, which indicated that CXCR4 played a vital role in breast cancer bone metastasis.@*CONCLUSIONS@#The bioinformatics analysis of CXCR4 can provide a certain basis for the occurrence and diagnosis of breast cancer bone metastasis, target gene therapy and evaluation of prognosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Bone Neoplasms
/
Breast Neoplasms
/
Molecular Sequence Data
/
Gene Expression Regulation, Neoplastic
/
Up-Regulation
/
Chemistry
/
Sequence Alignment
/
Amino Acid Sequence
/
Computational Biology
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2013
Type:
Article
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