Effect of Chinese herbal compound on liver fibrosis in rabbits with schistosomiasis by B-ultrasound
Asian Pacific Journal of Tropical Medicine
;
(12): 658-662, 2013.
Article
in English
| WPRIM
| ID: wpr-819986
ABSTRACT
OBJECTIVE@#To explore the value of B-ultrasound on the evaluation of the effects of traditional Chinese medicine compound of Radix astragali, Salvia miltiorrhiza and Angelica sinensis, and TCM + praziquantel on liver fibrosis in rabbits with schistosomiasis.@*METHODS@#The hepatic fibrosis model in rabbits with schistosomiasis was established. The experimental animals (24 rabbits) were randomly divided into four groups (group A, B, C and D, n=6). Group A (control group) was only treated by praziquantel; Group B was treated by mixture of Radix astragali and Salvia miltiorrhiza + praziquantel; Group C was treated by mixture of Radix astragali and Angelica sinensis + praziquantel; Group D was treated by mixture of Radix astragali, Salvia miltiorrhiza and Angelica sinensis + praziquantel. Then B-ultrasonogram was used to evaluate the effects.@*RESULTS@#Each group showed certain curative effect on liver fibrosis in rabbits with schistosomiasis. The efficacy of group B, C and D was better than group A, and that of group D was the best. The differences in long diameter, thickness diameter, transverse diameter and portal vein inner diameter of liver before and after treatment were statistically significant (P<0.05). The liver function indexes and liver fibrosis indexes were significantly improved after treatment (P<0.05).@*CONCLUSIONS@#The mixture of Radix astragali, Salvia miltiorrhiza and Angelica sinensis combined with Western medicine treatment can obviously improve the efficacy on liver fibrosis of schistosomiasis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Praziquantel
/
Schistosomiasis
/
Diagnostic Imaging
/
Chemistry
/
Ultrasonography
/
Treatment Outcome
/
Angelica sinensis
/
Salvia miltiorrhiza
/
Herbal Medicine
Type of study:
Diagnostic study
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2013
Type:
Article
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