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SIRT3 expression in hepatocellular carcinoma and its impact on proliferation and invasion of hepatoma cells
Asian Pacific Journal of Tropical Medicine ; (12): 649-652, 2013.
Article in English | WPRIM | ID: wpr-819988
ABSTRACT
OBJECTIVE@#To observe expression of SIRT3 in normal liver tissue, cirrhotic tissue and hepatocellular carcinoma (HCC) tissues, and to explore the significance of SIRT3 in primary HCC.@*METHODS@#SIRT3 expression was detected in 10 normal cases, 30 cases with, 30 HCC cases by immunohistochemical and Western-blotting method.@*RESULTS@#Immunohistochemical assay showed that the SIRT3 positive expression rates were 100.0% (10/10), 96.7% (29/30) and 60.0% (18/30), respectively in normal group, paracancer group and HCC group. And the SIRT3 expression in HCC group was significantly lower than in normal group and paracancer group (P<0.05). Western-blotting showed the SIRT3 expression in cancer tissue was 0.29±0.07, significantly lower than that in paracancer group and normal group (P<0.05). SIRT3 expression was related to the differentiation degree and portal vein tumor thrombus (P<0.05).@*CONCLUSIONS@#Abnormal expression of SIRT3 is closely related to the biological behavior of primary HCC.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Physiology / Immunohistochemistry / Carcinoma, Hepatocellular / Hepatocytes / Cell Proliferation / Sirtuin 3 / Liver / Liver Cirrhosis / Liver Neoplasms Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Asian Pacific Journal of Tropical Medicine Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Physiology / Immunohistochemistry / Carcinoma, Hepatocellular / Hepatocytes / Cell Proliferation / Sirtuin 3 / Liver / Liver Cirrhosis / Liver Neoplasms Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Asian Pacific Journal of Tropical Medicine Year: 2013 Type: Article