Cytokine levels in patients with chikungunya virus infection
Asian Pacific Journal of Tropical Medicine
;
(12): 631-634, 2013.
Article
in English
| WPRIM
| ID: wpr-819992
ABSTRACT
OBJECTIVE@#To investigate cytokine profile in patients with chikungunya virus (CHIKV) infection.@*METHODS@#Twenty eight pairs of serum samples collected from CHIKV infected patients during the outbreak of chikungunya fever in South Thailand in 2008 were obtained. A multiple cytokine assay for detection of 17 cytokines was performed.@*RESULTS@#In the acute stage of CHIKV infection, the patients had significantly higher levels of interleukin-6, granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein 1 and tumor necrosis factor alpha than the control (P<0.001, P=0.023, P=0.015, P<0.001 and P=0.024, respectively). When the disease developed to the recovery stage, the patients had significantly lower levels of interleukin-6, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein 1 and macrophage inflammatory protein beta than in the acute stage (P<0.001).@*CONCLUSIONS@#This study provides additional information that these cytokines could play roles in pathogenesis of CHIKV infection and could be used as disease biomarkers or drug targets.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Thailand
/
Blood
/
Chemistry
/
Chikungunya virus
/
Epidemiology
/
Disease Outbreaks
/
Cytokines
/
Alphavirus Infections
/
Serum
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2013
Type:
Article
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