In-vitro scolicidal activity of Mallotus philippinensis (Lam.) Muell Arg. fruit glandular hair extract against hydatid cyst Echinococcus granulosus
Asian Pacific Journal of Tropical Medicine
;
(12): 595-601, 2013.
Article
in English
| WPRIM
| ID: wpr-819996
ABSTRACT
OBJECTIVE@#To investigate new scolicidal agent from natural resources to cope with the side effects associated with synthetic drugs in Echinococcosis.@*METHODS@#The scolicidal potential of methanolic fruit powder extract (10 and 20 mg/mL) of Mallotus philippinensis (M. philippinensis) was investigated. Viability of protoscoleces was confirmed by trypan blue exclusion method, where mortality was observed at concentration of 10 and 20 mg/mL in 60 min treatment against Echinococcus granulosus (E. granulosus), under in-vitro conditions with reference to the known standard drug Praziquantel®.@*RESULTS@#At concentration 10 and 20 mg/mL, the mortality rate was observed 97% and 99% respectively for 60 min treatment; while up to 93% mortality was observed with 20 mg/mL for only 10 min treatment. The concentration above 20 mg/mL for above 2 h showed 100% mortality, irrespective of further incubation.@*CONCLUSIONS@#As compared with the standard anti-parasitic drug Praziquantel our extract has significant scolicidal activity with almost no associated side effects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Praziquantel
/
Biological Assay
/
Plant Extracts
/
Survival Analysis
/
Chemistry
/
Mallotus Plant
/
Echinococcus granulosus
/
Fruit
/
Anthelmintics
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2013
Type:
Article
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