Inhibitory effect of the paraoxonase gene on the formation of rabbit coronary atherosclerosis
Asian Pacific Journal of Tropical Medicine
;
(12): 544-547, 2013.
Article
in English
| WPRIM
| ID: wpr-820004
ABSTRACT
OBJECTIVE@#To observe the effect on the inhibition of coronary atherosclerosis hardening of the paraoxonase gene (PON-1) which transfected to the rabbit epicardial adipose tissue.@*METHODS@#Rabbit coronary atherosclerosis model was established by high-fat feeding, liposome-encapsulated recombinant plasmid pEGFP-PON-1 50 μ L was injected to the rabbit pericardial cavity, and was harvested 4 weeks after transfection.@*RESULTS@#The epicardial fat transfected PON-1 gene had effect on the high lipid level. It significantly increased expression of PON-1 in peripheral arterial vascular tissue (P <0.05); and significantly reduced total cholesterol and low-density lipoprotein cholesterol levels (P<0.05), and the thickness ratio of coronary artery intima/media (P <0.05).@*CONCLUSIONS@#The injection of the PON-1 gene in the pericardial cavity can effectively suppress the formation of coronary atherosclerosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Triglycerides
/
Coronary Artery Disease
/
Transfection
/
Genetic Therapy
/
Random Allocation
/
Cholesterol
/
Analysis of Variance
/
Aryldialkylphosphatase
/
Genetics
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2013
Type:
Article
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